Abstract In Malaysia, Entada spiralis Ridl. from Leguminoceae family grows wildly and the scientific study of it has not been explored deeply. Entada spiralis Ridl. is a liana or woody climber plant which is locally known as "akarbeluru" or "Sintok". This study is performed to evaluate the antibacterial activity of Sintok extract from the stem bark of Entada spiralis against skin bacteria infections by the disc diffusion method. Two types of skin bacteria known as Staphylococcus aureus and Streptococcus pyogenes were selected and tested against the water extracted Sintok. Sintok concentration of 1600mg/ml gave the highest inhibition zone diameter against Streptococcus pyogene rather than Staphylococcus aureus with a diameter of 25.5 mm and 18. mm, respectively. This study indicates clear evidence supporting the traditional use of Entada spiralis in treating skin infections related to bacteria.