Introduction: Lower-extremity artery disease is a major contributor to morbidity and mortality in the middle-aged and elderly. Atheromatous narrowing or blockage of a leg artery or arteries is a common cause of this condition. Possible symptoms include claudication episodes, pain during rest, sores, and even gangrene. Methods: In this prospective study, we will evaluate the precision of Duplex Ultrasound to that of MDCT angiography. Thirty-four patients with unilateral or bilateral lower limb ischemia illness who presented to the radiology division for CT angiography made up the study population. Department of Radiology, Kamineni Academy of Medical Sciences and Research Centre (KAMSRC), Hyderabad, was the location of the study and study between June, 2021 to May, 2022. Results: Thirty individuals were enrolled in the study. Twenty-six patients were 40 or older, while another six were 60 or older. Two patients needed below-knee amputations. Even though 830 artery segments from 67 limbs were analysed using the two approaches, only 806 were available for comparison. Conclusion: Therefore, due to its lack of danger, low cost, non-invasiveness, widespread availability, and excellent diagnostic accuracy, Duplex Ultrasound is an essential tool in the study of peripheral vascular disease.