At the nexus of genetics and healthcare, the powerful fields of pharmacogenomics and personalized medicine have evolved, revolutionizing both the prescription of pharmaceuticals and the provision of patient care. Pharmacogenomics receives attention because of its potential to enhance drug therapy and reduce negative side effects. Pharmacogenomic testing helps to identify genetic variations among people who are get affected drug response and metabolism. The goal of personalized medicine is to increase therapeutic efficacy while lowering the risk of adverse events by customizing a patient's course of therapy based on the genetic profile. Improvements in patient outcomes has become possible by pharmacogenomics' significant achievements in fields like oncology, psychiatry, and cardiovascular medicine. Prospects for pharmacogenomics and personalized medicine are very positive. Pharmacogenomic testing capabilities will increase because of the quick development of genomic technologies like highthroughput genotyping and next-generation sequencing. Additionally, pharmacogenomic data linkage with electronic medical records and decision support systems will improve clinical implementation. Personalized therapy suggestions can be created using artificial intelligence and machine learning algorithms after extensive analysis of patient data that considers clinical, genetic, and lifestyle aspects.