Background: Musculoskeletal pain (MSP) is a major cause of chronic pain, injury, illness, reduced educational attainment that may affect the quality of productivity, neck pain (NP) is a common condition affecting as much as two-thirds or more of the general population,low back pain (LBP) is social and economic health problem that affects population of all ages globally. Objective: To assess prevalence and associated risk factors of neck and low back pains among students at Faculty of Medicine, Zagazig University. Patients and methods: This study was a cross sectional study conducted on 382 students at Faculty of medicine, Zagazig University. From September, 2018 to April, 2019, they completed the questionnaires (self-administrated or online questionnaire) in the English language. Results: The prevalence of neck pain and/or low back pain among the studied group of students was 81.1%. NP presented in 74.4% while LBP detected in 73.1% of all studied students where 66.4% of participants reported both NP & LBP, the significant predictors of NP & LBP were studying more than 6 h/d, ergonomic problems and poor psychological studying environment (p<0.005, <0.005, <0.001 respectively). Conclusion: This study demonstrated high prevalence of NP &/ or LBP 81.1% among medical students at Faculty of medicine, Zagazig University, Students complaining from NP and/or LBP had longer studying and reading time, presented mostly in clinical years in addition they had ergonomic problems and poor psychological studying environments.