Background: Sickle cell disease (SCD) is the most prevalent monogenic inherited blood disorder worldwide, and is increasingly recognized in developing countries like India. SCD mostly occurs in rural tribal regions and low socio-economic group population Aim: this study evaluate the prevalence of sickle cell disorder in central Indian population Material & Methods: A cross-sectional study was carried out among 1 to 55 years age group population in a tertiary care center, Madhya Pradesh, India Detailed information regarding the family history, socio-demographic profile was inquired. Thorough general and systemic examination was done. Haemoglobin estimation, sickling test and haemoglobin electrophoresis was performed