Recently there has been a shift in universal trend from synthetic to herbal medicine, which we can say “Return to Nature‟. Medicinal plants have been known for millennia and are highly esteemed all over the world as a rich source of therapeutic agents. Botanical medicine represents an important share of the pharmaceutical market. Natural products compounds discovered from medicinal plants (and their analogues thereof) have provided numerous clinically useful drugs in the treatment of chronic and or acute disease and still remain as an essential component in the search for new medicines. So, these traditionally used plants can be explored effectively in order to find New Chemical Entity for the treatment of chronic and acute disease. The herbal industry shares about US $100 billion with good growth potential. Hence this field is having greater future perspectives. Review was performed systematically by review of literature published in journals and websites of different regulatory agencies, then after study of all the literatures which will summaries details related to registration of herbal product in Mexico. It covers legal aspects, procedural details, GMP and labeling requirements. It is very common trend globally to register herbal medicines and Mexico is one the country in that list. So the present work might provide a path for pharmaceutical companies who wise to sell their product in Mexico. This paper gives details about registration of herbal medicines in Mexico.