Introduction: Hypertension is a serious health problem worldwide. From 1990 to 2016 the hypertension cases increased from 0.78 to 1.73 crores. The majority of the patient has a lack of specific knowledge on hypertension. Deficient knowledge is one of the important etiological cause of stroke, coronary disease, and other non-communicable diseases. The major objectives of this study are to find out the correlation between the patients’ knowledge on antihypertensive and adherence to medication among patients with hypertension in selected hospitals in Khurdha and to find out the patient knowledge and medication adherence association with selected socio-demographic variables. Methodology: It was a correlational study conducted among 254 hypertensive patients attended at the Medicine OPD, IMS SUM Hospital Bhubaneswar, Odisha selected through simple random sampling. The data were collected by a self structured questionnaire. Results: The study findings showed that among the total participant's majority of them were between the age of 40-60 years (45.3%) and more than half of the participants were (63.4%) were females. The majority of the participants have had a knowledge on the treatment aspects (57.48%) and the medication adherence (63.78%) of hypertension. The hypertension knowledge of the high blood pressure patients showed that around 87.8% of participants had a poor on hypertension management knowledge. Majority of the participants had low medication adherence. The Knowledge of anti-hypertensives and adherence to medication among hypertensive patients have a significant weak positive correlation. Conclusion: Hypertension is an important risk for non-communicable diseases. Knowledge of hypertension can reduce the risk of hypertension complication.