Pandemics are defined as large- scale outbreaks that can greatly increase mortality and morbidity over a wide geographic area and cause significant economic, political and social disruption due to spread of infectious disease. Risk of pandemic and epidemic conditions have occurred throughout history and appear to be increasing in frequency, particularly because of the increasing emergence of viral disease from animals. Other associated risk factors include older age, longer hospital stays, immunosuppression, frequent encounters with healthcare facilities, mechanical ventilatory support, multiple underlying chronic illnesses, recent invasive procedures, indwelling devices and being in a critical care unit. Management of acute infections transmitted to susceptible patients via cross infections and emergence of antimicrobialresistant pathogens need attention in a hospital set-up. Task forces committee are organisations of small groups of resources and people brought together to establish a specific objective, to complete the expectation that the group will disband when the objective has been completed. The task force committee is actively involved in resolving issues on hospital acquired infection during pandemic and epidemic outbreak of disease and this review underpins the same.