ABSTRACT: Peridontitis is a multifactorial disease which is found to cause destructions to the supporting structures of the tooth which inturn is found to cause tooth mobility.It has been found that periodontitis is also interlinked with many metabolic disorders incuding diabetes mellitus.Diabetes mellitus is found to cause deletorial effects in many organs including the bone.In recent years a protein called sclerostin has been identified which is found to inhibit the Wnt signalling pathway which is one of the major pathways for bone formation.Hence this reiew aims atexplaining the importance of sclerostin and its link with priodontitis and diabetes mellitus thereby finding the sclerostin protein as a potential biomarker for periodontitis and whose therapeutic use may help in future.