In this review we aim to discuss the clinical utility of stem cells in regeneration of periodontal tissue from recent studies. We contemplate the main stem cells used for periodontal regeneration, along with bone marrow-derived mesenchymal stem cells. Furthermore we elaborated about the stem cells derived from dental pulp, periodontal ligament, exfoliated human deciduous teeth, apical papilla along with dental follicle precursor cells. These stem cells in future can be utilized for the tissue regeneration in periodontal treatment.