Blood transfusion services are the most important part of modern health care system and maintaining the adequate supply of safe blood is an ever challenging job for blood banks. The most important is the selection of blood donors by donor selection criteria. Blood donor deferral is a very painful and sad experience, but retaining them for future is a very challenging job. Hence we studied the current rate and various reasons and demographic pattern for donor deferral in this blood bank. Study of deferral of blood donor at collection site and donor blood deferral in blood bank will be worthwhile and enlightening. It will help in taking corrective measures and improving strategies for donor motivation.