Chronic Obstructive Pulmonary Disease (COPD) is a name coined for the diseases previously known as chronic bronchitis and emphysema. COPD is defined as common preventable and treatable disease characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. This study was planned to observe the evidence of systemic inflammation in different stages of COPD. The present study was a cross sectional study carried out in 100 stable male COPD patients. Following inflammatory parameters were included in study , C- Reactive Protein (CRP) , Erythrocyte Sedimentation rate (ESR), Differential leucocyte count (DLC): neutrophil count (%) , Total leucocyte count (TLC). 100 Subjects were divided in four groups from mild to very severe (GOLD stage I-IV) according to spirometry values based on FEV1% predicted and FEV1/FVC ratio < 0.7. Then changes in systemic inflammatory parameters in different stages of COPD were observed applying ANOVA test. P value <0.05 was considered statistically significant. TLC was significantly increasing (p<0.05) as the severity of COPD increases. Neutrophil count also significantly increased with GOLD, COPD stages (p<0.5). Mean values of ESR showed an ascending pattern as the severity of disease progressed but it was not statistically significant (p >0.05). CRP level was elevated in most of the patients of severe (III) and very severe (IV) patients suggesting presence of systemic inflammation. As COPD is a multifactorial heterogeneous disease so, for determining the severity of COPD, other parameters such as inflammatory markers which will predict the morbidity as well mortality of the patients should be included.