New anti UV- reactive dyes (1-4) were synthesized from its structure was confirmed by 1HNMR and IR spectroscopy and their dyeing behavior and ultraviolet (UV) protection on cotton and wool fabrics were investigated. From the study, we can see that the exhaustion value reached over 85%, the T (UVA) and T (UVB) were 3.3% and 3.4%, respectively. The fabric dyed with anti UV- reactive dyes had very good ultraviolet radiation protection. The effects of varying dyeing conditions were investigated. Fabrics dyed with anti-UV dyes were tested for color strength (K/S), rate of fading (∆E) values. The dyed fabrics also showed very good light fastness and good to excellent washing, rubbing, and perspiration fastness. In this paper our work aiming to reduce the undesirable photodegradation effects of UVR on dyed fabrics by applying these new anti UV- reactive dyes.