Background: It is well known that thyroid dysfunction as well as adipokines have an important effect on lipid profile. However, the effect of adipokines on lipid profile in hyperthyroid patients is not well elucidated. Objective: This study aimed to examine changes in serum lipid profile and to evaluate the correlation between these changes and the adipokines chemerin, visfatin and omentin in Saudi female patients with hyperthyroidism. Materials and Methods: A total of 140 participants were recruited for this study. The participants were sub-grouped as a control group (n = 70) and hyperthyroid patient group (n = 70). Serum adipokines (chemerin, visfatin and omentin), lipid profile, thyroid profile (TSH, FT3, FT4, TT3, TT4 and Thyroxine) and thyroglobulin were measured for all participants. Results: Serum concentrations of total cholesterol and low-density lipoprotein cholesterol (LDL-c) were significantly lower in the hyperthyroid patients than in the control group. Thyroid hormones TT3 and TT4 were positively correlated with triglycerides, while FT3 was negatively correlated with total cholesterol and LDL-c. Although visfatin and omentin showed no significant correlation with lipid profile, chemerin was positively correlated with triglycerides and negatively correlated with high-density lipoprotein cholesterol (HDL-c). Conclusion: The changes in chemerin concentration that occur in hyperthyroid patients play a role in regulating lipid metabolism and may lead to dyslipidemia.