Abstract Background: Migraine pain is a primary headache disorder characterized by recurrent headaches that are moderate to severe. Objective: To evaluate the effect of noninvasive pulsed radio frequency (pulsed RF) in Migraine. Methods: In a prospective study of the intervention performed in adult population with Migraine (Diagnosed by specialists) carried on (30) patients undergone pulsed RF for greater and lesser occipital nerves to control recurrent migraine not responding to conventional treatment (resistant) in a period from Jan. 2017 to Jan 2019 in Al Safeer Hospital for surgical specialties and Alkafeel Hospital for surgical specialties both in Karbala / Iraq. The patients got in prone position under local anesthesia with goal positions with the target sites obvious out using anatomical breakthroughs and the position of greatest ache. Pulsed RF by RF needle to the affected side to reach greater and lesser occipital nerves then got 3 sessions (each for 3 minutes, temperature 42 C, voltage 42 V, resistance with 100 Ohms, Current with 230 mA) Patients monitored post-operatively for 2 hours then discharged. Follow up at intervals of 30 days, 6 months and 1 year by phone call or direct interview to assess the post procedure pain scale. Result: Significant pain relieve by means of no or little pain medication and actual life pattern change and performance in 1-year post procedure. Conclusion: A single trial of pulsed RF is effective for pain reliever.