Raw guggulu use has been linked in rare cases to skin breakouts, periods that are irregular, diarrhoea, headaches, mild nausea, and, at very high doses, liver damage, as documented in Ayurvedic texts. Many "dravyas," or fluids, employed in Ayurvedic purification rituals (shodhan vidhi) may be utilised to dilute the potentially harmful effects of uncooked guggulu while amplifying its medicinal properties. According to Ayurvedic texts, guggulu must be purified before it may be employed in herbal combinations. Many popular polyherbal pain relievers on the market centre on guggulu.