Objectives: Parkinson's disease (PD) represents a multi-part progressive neurodegenerative disease described by rigidity, bradykinesia and tremor in addition to postural unstable appearing of patients as the disease progress. The purpose of this study evaluate of some parameters (Ca+2 , Vitamin D, C, E and phosphorus) in sera of PD Iraqi patients. Methods: Two main groups were included in this study; 55 patients (22 male &23 female) with PD (patients group) and 30 (11male & 19 female) apparently healthy controls (control group) without a history of PD were involved in the current study. Results: Vitamin D in the sera of patient group was a highly significant decrease (p<0.001) in comparison to the control group while highly significant decrease (p<0.001) in the calcium levels of patient group, as well as highly significant decrease (p<0.001) in the phosphorus of patients group was observed in comparison with their levels in corresponding control gruop. Meanwhile, a significant decrease (p<0.05) in vitamin C of patients group when compared to that of control group and a highly significant decrease (p<0.001) in serum vitamin E concentration of patients group when compared to that of control group. Conclusion: The current study results show a deficiency in most antioxidant parameters [vitamin D3, E, C and phosphorus] that may subsequently lead to their inability to suppress free radicals and thus lead to oxidative stress. This leads to relapse and the progression of patients' condition for the worse.