Objectives: The primary objective was to assess the level of stress-related to work and quality of sleep among intern nursing students. The secondary objective is to determine the level of work-related stress& its association with the demographic variables. Methods: This was a descriptive study conducted among 160 internship students. The subjects were selected conveniently and interviewed through a self-structured demographic Performa.PSQI sleep assessment scale and perceived stress scale were administered to assess the sleep quality and level of stress related to work respectively. Results: As per the survey results, with regards to work-related stress majority 64.4% of the subjects were having a moderate level of stress and a very few i.e 3.8% of the sample were having severe stress. In the case of sleep quality among interns, more of the samples (83.3%) were having the average quality of sleep and only 6.2% of samples were having good sleep quality. There is an extremely statistically significant association between age, gender, sleeping pattern and working sector with work-related stress whereas there is no significant association between caffeine intake, educational status and work duration with quality of sleep. Conclusion: This study may bring light to the prevalence of work-related stress and quality of sleep among nursing interns, so that faculty may find out the aggravating factor causing stress among interns and quality of sleep so that guiding and motivating the interns to overcome the factors successively and to improve better health care outcome.