INTRODUCTION: Fatty liver disease is a broad term for the accumulation of triglyceride fat in the liver. Fatty liver disease has been linked to higher levels of different circulating inflammatory markers. The current study compared the inflammatory markers of patients with alcoholic fatty liver disease (AFLD) with non-alcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: This descriptive study included 60 individuals with fatty liver disease (30 NAFLD, 30 AFLD). Venous blood samples were taken from fasting patients to assess inflammatory markers (CRP, IL6, TNF α). Statistical analysis was performed using the Student's t test, with p-values < 0.05 considered significant. RESULTS: The mean values of Inflammatory markers (CRP, IL6 and TNF-α) in the NAFLD group were 01.86±0.57, 27.65±13.58, 34.86±12.34 and in the AFLD group were 01.97±0.74, 29.37±12.19 and 36.12±16.12. There were no significant changes in CRP, IL6, or TNF-α levels between AFLD patients and those with NAFLD. CONCLUSION: Fatty liver disease is related with elevated inflammatory markers. Because increased inflammatory markers in fatty liver disease indicate liver injury, assessing inflammatory markers should be prioritized in the therapy of fatty liver disease patients.