The global pandemic caused by severe acute respiratory syndrome (Corona virus disease - COVID-19) is the major concern of mankind now. The tiny virus has wiped out million of lives and changed the total economic scenario of world. The present review is formulated with a view to study and analyse the epidemics of first and second wave of COVID-19 in relation to its effects on human health. The infection pattern has been changed and many countries have witnessed higher number of people infected in the second wave than the first one. The result of stimulation suggests that the second wave may occur in the mid July 2020 to the last week of December 2020. One of the main problems in managing the COVID-19 epidemic crisis in second wave is its effects on human health and disease syndrome as compared to the first wave of COVID-19 and also the technical and calculated capabilities of nations. According to scientists, 18 mutations in 7 genes have been observed as a result of mutation and the new variant has been named B.1.617. The pair of spike genes has been linked to amino acid deletion and the ability to evade vaccines. As a result, he is entering the receptor faster and infection is spreading rapidly. Corona virus enters the human body through this spike protein. In India RT-PCR tests are targeted at three genomic sequences of viruses. Only if three different genomic sequences match then there will be a positive report.