Introduction: Leukemia is malignant neoplasm of the hematopoietic stem cells characterized by diffuse replacement of the bone marrow and/or peripheral blood by neoplastic cells. As per available information from population based surveys, the incidence of leukaemia in India varies from 0.8/1, 00,000 in Barshi (Rural area of Maharashtra) to 5/1, 00,000 in Delhi. Aim: to study clinical characteristics of acute leukaemia in central India at a tertiary health care centre. Methodology: Cases for the study collected from Sri Aurobindo Medical College and PG Institute Hospital wards attached to Department of Medical Oncology. The study comprises 106 cases of acute leukaemia. Study period was from November 2015 to November 2017. Results: Present study showed that prevalence of ALL (51.9%) was higher as compared to that of AML (48.1%).