Objective: To study the efficacy of 50 µg of Misoprostol tablet for induction of labor, oral v/s vaginal route. Methods: 100 women, at term gestation, with various indication for induction of labor with Bishop’s score of ≤4 were included. After deciding, 50 women received 50 µg orally and 50 women received 50 µg vaginally every fourth hourly (maximum of 6 doses) or till they went into active labor. Results: After statistical analysis it was found that in vaginal misoprostol route the induction to delivery interval was significantly less compared to oral misoprostol group (9.5 v/s 160). It was also found that the required dose of drug in vaginal route is less compared to oral route (40% of women need only 2 doses in vaginal group compared to 35% of oral group were 6 doses required). Conclusion: For induction of labor vaginal misoprostol is always more effective compared to oral route.