Online ISSN: 2515-8260

A Comparison of Ketamine-Propofol Versus Propofol as Induction Agents on Hemodynamic Parameters in Patients Undergoing Elective Surgical Procedures Under General Anesthesia

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Prathap Sidda1 , Jhansi Gurram

Abstract

Background:Propofol produces quick induction and recovery, depresses airway reflexes, and is used for sedation and anaesthesia; nevertheless, it is associated with dose-dependent hypotension and respiratory depression.It can produce coughing, hiccups, laryngospasm, and movements when used as a sole agent to provide LMA.In addition to its amnesic and analgesic effects, ketamine raises heart rate and blood pressure through stimulating the sympathetic nervous system.It was shown that a combination of ketamine and propofol decreased patients' use of propofol and opioids and improved their hemodynamic and respiratory stability. Objectives:1. Determine whether the ketamine-Propofol combination has more favourable hemodynamics than the gold standard prototypic induction drug (Propofol) in a cohort of healthy patients.2. To compare the additional post-operative analgesia requirements between the two groups.

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