Pain is the most distressing symptom of the individual, cancer related distressing symptoms precisely limits the once own forbearance.Cancer pain is the big burden which can be carried by the individual temporarily or throughout their treatment or end of life. Cancer related distressing symptom management is a very big challenge, which can be achieved in multidisciplinary and holistic approach. Review of literature was made by using the databases of MEDLINE and PUBMED of articles published between 2003 and 2019. Quality standard selected domains based on the cancer pain and cancer related distressing symptoms in non- pharmacological aspects. In order to manage the cancer related symptoms through multidisciplinary and holistic approach as “CASH. Along with pharmacological method and adjuvant therapy of non-pharmacological modalities gives the better opportunity to improve their QOL. Effective care achieved by update of knowledge and skill of the nursingpersonnel and application of the therapies in holistic approach to reduce the distressing symptoms and improve their health related quality of life.