Aim: Comparison effect of intravenous tranexamic acid and misoprostol for postpartum haemorrhage. Methods: This double blinded randomised clinical trial study was done the Department of Obstetrics and Gynaecology, Hi-Tech Medical College, Rourkela, Odisha, India from February 2021 to November 2021. 80 women with PPH (500-1500 ml) diagnosis after caesarean or normal delivery, according to their haemorrhage level after usual therapies for controlling haemorrhage, after getting consent were included in the study. They were divided into two equal intervention and control groups randomly. Patients in group A were treated with intravenous TXA and patients in group B with rectal Misoprostol. Intervention group (group A) which were receiving intravenous TXA (1gr) and if there was relieve in haemorrhage, next TXA dose was repeated after 30 minutes and in patients of control group (group B) after usual therapies, 5 rectal 200 micrograms Misoprostol pills were used. The bladder was emptied before therapy in both groups.