Introduction: Hospitalization can bring lots of emotional changes in children and their families. Children may find different routines, strange faces; limited family contact and it will produce anxiety in children. Title: A quasi experimental study to assess the effectiveness of Art therapy on level of anxiety among hospitalized children in selected hospitals of Pune city. Objectives: To assess the level of anxiety among the children in experimental and control group. To determine the effectiveness of the art therapy on level of anxiety. To compare the effectiveness of art therapy on the level of anxiety among the children in experimental and control group. Material and methods: In order to achieve the desired goal of the study Quantitative research approach with Quasi experimental Non- equivalent pre test post test control group design was used for the study. Using Non- probability purposive sampling technique 60 hospitalized children both males and females having age group of 3-6 years and admitted first time in the hospital were selected and sample was distributed in two groups (30 each in control and experimental group). Data collection was accomplished by using tool five facial anxiety scales. Data was analyzed through descriptive and inferential statistics. Results: The findings shows that in experimental group the test p-value was < 0.001 so there was statically difference between the median score of the pre and post test facial anxiety scale. Whereas in control group the test p value was 0.405, it shows that there is no significant difference between median score of the pre and post test facial anxiety scale. Conclusion: The study findings show that reduction in the level of anxiety after administration of Art therapy. Nurses have to play important role to participate in art therapy in reducing the anxiety of hospitalized children.