Family planning survives are the process that persons or couples look forward to attain their desired numbers of children and prepare plan for length of between births. Family planning clear affect the health of women, children, and families economical and socially on worldwide especially those in developing countries. That is family planning helps women avoid unplanned or unwanted pregnancies, and prevent unsafe abortions. This study aimed to identify factors that affect women’s family planning practice in Ethiopia. In this study, the data source is EDHS 2016 with a total of 4,392 women of age 15-49 years. Descriptive statistics, single level multinomial logistic regression model were used for statistical analysis. Descriptive result show that about 23.9% of the women practiced family planning while 76.1 % did not practice family planning method. The multinomial logistic regression analysis revealed that the independent variable like place of residence, age of a woman, religion of a woman, educational level of women, wealth index, heard FP method by TV in the last 12 month, visited health facility last 12 month, heard FP method on radio in the last 12 month, marital status, desire to more children, women currently working, number of living children of women and visited by FP worker in last 12 months were found to be significant predictors for women’s family planning practice. The study recommends government and nongovernment organizations should focus on educating women and improving employment opportunities for, Promote family planning by providing better information, supply, access and services about family planning as well as good health centers across all the country.