Background: The mortality rate covid-19 is still not understood completely but was reported around five percent worldwide. This study puts in an effort to find one such difference if any between the survivors when compared to the non-survivors. This study makes an effort to find the acute inflammatory proteins in the survivors in comparison with the non-survivors. Aims and Objectives: To study the acute inflammatory proteins levels and their significance in Covid-19. Materials and Methods: This is a retrospective study done in the Department of Medicine, Dr. Chandramma Dayanand Sagar Institute of Medical Education and Research, Bangalore. Results: There is a significant difference in the levels of acute inflammatory protein levels in survivors when compared to that of non-survivors. Conclusion: This study successfully portrays the importance of acute inflammatory protein levels in understanding the progression of the disease.