Background: The aim is to study the serum electrolyte levels in thyroid patients attending a tertiary care hospital. Materials and Methods: Thyroid hormones plays vital role in maintaining body's metabolism, BMR, thermoregulation and hemodynamic status and present study was prospective study done in the patients attending TRR Medical College & Hospital. The study was conducted over duration of 2 years from December 2019 to June 2021. All the patients in the age group of 18- 40 years were taken in the study. Total 100 patients were included in the study (50 cases, 50 controls) to study the evaluation of serum electrolytes on thyroid patients.