Introduction: Acute ischaemic infarction is the third etiology of death and first etiology of disability across the globe. Cerebrovascular accident is an emergency condition requiring immediate intervention. The blood brain barrier compromised in patients with acute ischaemic stroke, leakage of neuro-biochemical protein markers like NSE into the peripherial circulation allow pathogenesis and prognostication of patient‘s with CVA to be weighed up additionally. The current work structured to determine the marker of braindamage, NSE in serum of patient‘s with acute ischaemic infarction as a diagnostic and/or monitoring tool for early prognosis of ischaemic stroke.