Introduction Contact dermatitis is an inflammatory eczematous skin disease. It is caused by chemicals or metal ions that exert toxic effects without inducing a T-cell response (contact irritants) or by small reactive chemicals that modify proteins and induce innate and adaptive immune responses (contact allergens). Material and Methods A total of 100 patients of contact dermatitis of either sex who attended the Out-Patient Department of Dermatology, Venereology and Leprosy at Tertiary care teaching hospital over a period constituted the subject material for the present study. Inclusion Criteria: Patients clinically suspected to have contact dermatitis. Patients with active dermatitis were first treated and then subjected to patch testing so as to avoid false positivity and excited skin syndrome (Angry back syndrome). Result: In our study males (51%) outnumbered females (49%) in the study. Itching was the most common symptom (98%) followed by burning and oozing (10%). In this study, most commonly observed period was 1-5 years, as seen in 57% of the cases. Study sensitization to one antigen was seen in 40% cases, to two antigens in 27% cases, three antigens in 2% cases. Negative results observed in 31 % cases. Positive patch test results were noted commonly among the following occupations were labour (85.71%), farmer (66.66%), housewife (62.96%), mason (53.33%) cases respectively. Cosmetic allergens (P<0.0001) significantly more common in females. Parthenium (P<0.05) significantly more common in males. Conclusion In our study, the commonest allergens in our patients from hospital adjoining places were potassium bichromate, thiuram mix and parthenium in males, whereas nickel, fragrance mix and kumkum in females. In view of the differences in clinical patterns, positivity rates etc. reported from different parts of India, we owe it to our patients to clarify the epidemiology of this important problem.