Objective:To assess the knowledge and attitude regarding the health consequences of consanguineous marriage among the students of Khalikot University, Berhampur. Methods:An explorative study was undertaken where a total of 150 samples were taken using stratified random sampling and setting was selected through purposive sampling. The data were collected by using a socio-demographic Performa, structured knowledge questionnaire, and a structured Linkert attitude scale for assessing the knowledge and attitude of students regarding the health consequences of consanguineous marriage. Result:The study reveals that62% of students had moderate knowledge and only 12% of them have inadequate knowledge regarding the health consequences of consanguineous marriage.The mean knowledge score was 11.5 with SD= 3.12. It also reveals that 64% of students have a positive attitude towards the health consequences of consanguineous marriage. The mean attitude score was 68.8 with SD=7.84. A significant positive correlation was established between the knowledge level and attitude score of students on the health consequences of consanguineous marriage (r=0.017). It also showed a significant association of knowledge regarding the health consequences of consanguineous marriage with age, religion, monthly family income, and father’s educational status at 0.05 level of significance (p ≤0.05). Conclusion:Good strategic intervention needs to be adopted to aware and sensitize the people of a different section of the community regarding problems of marring close relatives through a widespread IEC and SBCC ( Social and Behavioral Change Communication) to prevent health consequences from consanguineous marriage