Physical training has always remained a suitable intervention to overcome the muscle degenerative situations such as sarcopenia not only in the old but also in late-adult and middle-age. This study is aimed to investigate the intervention of physical activity and naturally occurring biologically active compounds of medicinal value in addressing age related skeletal muscle changes. Basella albaalso known as Indian spinach has antiulcer potential, anti-inflammatory activity and hypo-glycemic activity, a natural antioxidant can offer better defense against age related changes in the supplemented physical trained rats. Rats were categorized into four sub-groups. Sedentary control, SE-C; sedentary supplemented, SE-C(S); swim trainees at thermo neutral temperature, SW-T(N) and supplemented swim trainees at thermo neutral temperature, SW-T(N+S). The results suggest that swimming is capable of improving skeletal muscle endurance and mass. Basella alba supplementation ameliorates the benefits of swim exercise.Basella alba and swim training showed changes and increase in the endurance capacity of skeletal muscles.