Background: Immunization can be defined as the process by which on individuals Immune system is enhanced, when it is exposed to the foreign practical to the body. Immunization stimulate own immune system and help to protect against infection. Aims- The aim was to find out knowledge of parents regarding care of the child after immunization in the age group of 0-5 years. Objective: To assess the knowledge of parents regarding care of the child after immunization in the age group of 0 -5 years. . Materials and Method-A Non experimental research design was adopted to conduct the study. A total 100 samples was selected by using non probability convenience sampling technique. Study instrument was self-structured questionnaire used by the researcher. Study was conducted for five paediatric OPDs or clinics of Pune district ( Olive Clinic Katraj, Saiseva clinic katraj, Speciality children’s clinic and vaccination Centre Narhe, Navjeevan clinic Dhayari phata pune and Sunita Nursing home Narhe) . Result- Majority of the parents have good knowledge score that is 95% regarding care of the child after immunization in the age group of 0 -5 years. There is no significant Association between the knowledge score and demographic data. Conclusion: The studies concluded that the parents have good knowledge regarding care of the baby after immunization.