: In Panchakarma, Nasya plays an important role in treating various diseases affecting Urdhwajatru (the part of the body above the shoulders) and the Central Nervous System. Human beings are considered to be in the form of Urdhvamulam Adhaha-shaka where proper irrigation of the Moola (root) will sustain the Sakhas (branches) in a healthy manner. There are different types of Nasya being described in this context. Nasapana is one such related procedure in which the medicines are introduced through the nasal pathway. Not many references are available in classics as well as contemporary literature regarding the same. In the absence of such references, following a Standard Operating Procedure (SOP) is required to demonstrate and replicate its safety cum efficacy. An observational study was done on 50 patients suffering from various diseases treated with a SOP developed on Nasapana. The dose, methods, sign and symptoms of Nasapana, complications and suitability of the same were studied in detail. Data related to patient, disease condition etc. were collected and observed for the safe execution of the procedure. Not a single case of complication was noted, but, in all patients the severity of disease got significantly reduced. It can be concluded that this SOP may be followed for doing Nasapana procedure.