In this review we have discuss about history and growth of mathematics along with chemistry. Since, chemistry is a practical science and it is focus on synthesis of new compound, hence there is broad scope of mathematics in chemistry and it is also very useful, because among other things, experimental work is guided by models which are produce by mathematics and which target the shortest possible route of experiments. This review also discusses the way of meeting of these two broad areas of sciences. A trial is taken to define mathematical chemistry. Mathematical chemistry is new branch of chemistry. We discuss about several practical ideas in the mathematical way. By discussing Weyl’s, Plato’s, Geoffroy’s, Mendeleev’s theory etc we want to highlight more application of mathematical chemistry branch in current scenario.