Background: A wide spectrum of pathologies involves the synovial lining of joints and periarticular tissues in human body. The present study was conducted to analyse the pattern of Synovial Lesions from Synovial Biopsies in a Tertiary Care Hospital. Materials & Methods: 180 synovial biopsies were included in the study. Relevant clinical and radiological details were obtained. All the biopsies were stained. The final diagnosis was made. The clinical and pathological data were collected. Based on histomorphology, lesions were classified under four categories that is inflammatory joint diseases, degenerative joint diseases, tumors, and tumor-like conditions. Results: In the present study, the common age group affected was above 65 years. Minimum patients were in age group less than 20. Most common symptoms were pain and swelling. Most common histopathological diagnosis in the study was chronic nonspecific synovitis (47.22%), followed by osteoarthritis (17.22%). Conclusion: The present study concluded that synovial lesions were most common in age above 65 years and the most common histopathological diagnosis was chronic nonspecific synovitis, followed by osteoarthritis.