Antimicrobial resistance has arisen as a considerable worldwide health predicament, especially in the framework of healthcare-connected infections (HAIs). HAIs occur during medical treatment and frequently affect vulnerable patient populations, resulting in elevated morbidity, mortality, and healthcare expenses. This abridgment scrutinizes the roots and repercussions of antibiotic resistance in HAIs. The leading cause of antibiotic resistance in HAIs is the superfluous and erroneous use of antibiotics. The broad and indiscriminate application of these medications has resulted in selective pressure on bacteria, advancing the endurance and propagation of resistant strains. Additionally, the spread of resistance genes between bacteria compounds the issue. Poor infection control methodologies, substandard hygiene, and unsatisfactory antimicrobial stewardship programs within healthcare centers also contribute to the generation and dissemination of antibiotic resistance. The aftermath of antibiotic resistance in HAIs is profound. Patients affected by antibiotic-resistant infections experience protracted hospital stays, heightened treatment shortcomings, and elevated mortality rates contrasted with those infected by susceptible pathogens. Moreover, the restricted availability of effective antibiotics obstructs treatment alternatives, leading to the use of last-resort antibiotics with latent toxicities and greater costs.