Aim: To assess knowledge and practice concerned with newborn care between staff nurses posted in postnatal wards of selected hospitals in Bhubaneswar. Methods and material: A descriptive survey approach was undertaken to evaluate the knowledge and practice regards to newborn care amongst staff nurses employed in postnatal words of IMS &SUM Hospital, Bhubaneswar. 50 samples were selected by purposive sampling technique and data was collected from the staff nurses through online mode. Result: The knowledge level of staff nurses about newborn care reveals that 04% of nurses having poor knowledge, 54% having average knowledge and 42% are having good knowledge. The level of practice among the nurses involving in newborn care reveals that no nurses were having poor skills regarding newborn care, 30% of staff nurses having average practice skills, 70% of staff nurses having good practice skills. Conclusion: Findings determined that nurses have knowledge and practice about the care of newborns but in newborn resuscitation cases there was some gap between knowledge and practice. Skills need to be improved.