ABSTRACT Background: To assess clinicopathological profile of acute pancreatitis patients. Materials and Methods: Seventy- six patients of acute pancreatitis of both genders were included. Types of pancreatitis, etiology of pancreatitis, clinical presentation, organ dysfunction, co-morbidities, complications, imaging profile and outcome was recorded. Results: Out of 76 patients, males were 46 (60.5%) and females were 30 (39.5%). Types of AP was acute interstitial in 48 and acute necrotizing in 28. Etiology was alcohol in 36, gall stone in 21, post ERCP in 10, autoimmune in 6, others (hypercalcaemia) in 2 and idiopathic in 1 case. Clinical presentation was abdominal pain in 54, jaundice in 37, vomiting in 40, pleural effusion in 22, anemia in 12, fever in 9, ascites in 8 and circulatory shock in 2 patients. Organ dysfunction was transient organ dysfunction in 28 and persistent organ dysfunction in 12. There was no organ dysfunction in 36 cases. The difference was significant (P< 0.05). Co-morbidities observed was diabetes mellitus in 7, hypertension in 6, chronic kidney disease in 2 and autoimmune disorder in 1 patient. CT severity index (CTSI) was 0-2 (mild) in 38, 4-6 (moderate) in 22 and 8-10 (severe) in 16 cases. Complications observed was sepsis in 3, liver dysfunction in 2, renal dysfunction in 1, pneumonia in 5 and pseudocyst in 2 cases. Outcome was cured 42, improved 29 and expired 5. The difference was significant (P< 0.05). Conclusion: Alcohol was the predominant etiology of acute pancreatitis. Most common type was acute interstitial.