Background: Oral cancer treatment can have a significant impact on patients' oral health and overall quality of life. This study aims to assess the effectiveness of dental rehabilitation in improving the quality of life of oral cancer-treated patients. Methods: A retrospective analysis of medical records was conducted. Patients who received dental rehabilitation following oral cancer treatment were identified. Dental rehabilitation interventions included prosthetic rehabilitation, dental implant placement, and oral rehabilitation therapy. Quality of life was assessed using the EORTC QLQ-C30 and OHIP-14 instruments. Statistical analysis included descriptive statistics and multivariate regression models. Results: The study included 238 patients with a mean age of 57.4 years. Prosthetic rehabilitation, dental implant placement, and oral rehabilitation therapy were associated with significant improvements in EORTC QLQ-C30 and OHIP-14 scores. For example, EORTC QLQ-C30 scores increased from 52.6 to 71.2 following prosthetic rehabilitation. OHIP-14 scores decreased from 28.4 to 14.7. Similar improvements were observed in other rehabilitation categories. Conclusion: Dental rehabilitation plays a pivotal role in enhancing the quality of life of oral cancer-treated patients. These interventions significantly improve functional aspects and psychosocial well-being, highlighting the importance of comprehensive oral care in the management of oral cancer.