Background:Pancreatic lesions are a difficult diagnostic and therapeutic challenge owing to the deep- seated location of pancreas. The present study was conducted to compare ultrasonography and computed tomography in the assessment of retroperitoneal masses. Materials & Methods:84 patients with signs and symptoms of retroperitoneal masses of both genders were enrolled. All underwent USG and MDCT. Data such as name, age, gender etc. was recorded. All underwent USG and MDCT. Ultrasound was performed with Logiq P9ultrasoundmachine. MDCT was performed with Siemens Somatom go 32 sliceCT machine. Characteristics like size, appearance, echotexture, vascularity and other findings were studied.