Background seasonal influenzavaccination is essential for population health. However, despite its strong recommendation, studies indicated a low rate of vaccine response. Influenza is a serious disease that can cause hospitalization, intubation, and death in high-risk groups. Influenza complications are due to changes in the immune, respiratory, and cardiovascular systems. Patients with an influenza infection are at increased risk of severe illness and complications and have a higher mortality and morbidity rate. Despite the significant role of seasonal influenza vaccination in preventing and minimizing the serious complications of influenza infection in patients, unsatisfactory compliance still exists for vaccination. Vaccination against influenza is the main way to reduce the substantial health burden that seasonal influenza causes, and is the primary tool to prevent influenza infection. The Advisory Committee on Immunization Practices at the US Centers for Disease Control and Prevention (CDC) recommended that all people above age 6 months receive the influenza vaccination annually unless contraindicated