Background: Metabolic syndrome (MetS), a serious universal health problem, is defined as the clustered presence of three or more conditions, including hyperglycaemia, hypertension, hypertriglyceridemia, low HDL-cholesterol and central obesity. The present study assessed the relationship between MetS and Periodontitis. Materials & Methods: In this case control study, 270 patients with metabolic syndrome aged 18-40 years of both genders (Group I) and equal number of age and gender matched healthy controls (n=270,Group II) were enrolled. Periodontal status was assessed using a community periodontal index (CPI). Score 0 (healthy), 1 (bleeding following probing), 2 (presence of dental calculus), 3 (probing pocket depth between 4 and 5 mm) and 4 (probing pocket depth ≥6 mm) was calculated. Results: Out of 540 patients, males were 258 and females were 282. Healthy periodontium was seen in 12% in group I and 45% in group II, bleeding in 5% in group I and 20% in group II, calculus in 20% in group I and 15% in group II, pockets 4- 5mm in 35% in group I and 13% in group II and pockets >6 mm was seen in 28% in group I and 7% in group II. The difference was significant (P< 0.05). Conclusion: There was poor periodontal status in patients with metabolic syndrome as compared to healthy subjects.