Background:Psoriasis is a chronic, immune-mediated skin disease. The present study was conducted to assess serum ADA and hsCRP level in psoriatic patients. Materials & Methods:66 patients of Psoriasis of both genders were divided according to PASI score <10 defined psoriasis asmild, between 10 and 20 as moderate, and >20 assevere. Each group contains 22 patients. 25 healthy subjects were included as a control group. Serum ADA and hsCRP levelwere measured in psoriatic patients. Results: Control group had 10 males and 15 females, mild had 13 males and 9 females, moderate had 12 males and 10 females and severe had 11 males and 11 females. ADA level was 8.2 U/L in control group and 23.1 U/L in psoriasis patients. The mean hsCRP level in control group was 9.0 ng/ml and 54.2 ng/ml in psoriasis group. The difference was significant (P< 0.05).