Background: Peri-implant disease is a chronic inflammatory condition caused by bacterialplaque contamination. The present study was conducted to assess serum Creactive level inpatientswith peri-implantitis. Materials & Methods: 40 radiographically and clinically confirmed patients with periimplantitis and equal number of controls was enrolled. Patients were divided into 2 groups.Group I was patients with peri- implantitis and group II were healthy control. Serum Creactiveproteins levelsweredetected with autoanalyser. Results: There were 25 males and 15 females in group I and in group II, 22 males and 28females. The mean serum C- reactive protein level in group I was 412.6 pg/ml and in groupIIwas 194.2 pg/ml. Thedifferencewas significant (P< 0.05). Conclusion: There was increased serum C reactive level in patients with periimplantitis.