Background:Coronary artery disease (CAD) has emerged as the major cardiovascular disease of the era and also the commonest cause of premature death. For several decades, conventional invasive angiography (CIA) has been considered as the well-established gold standard for making the diagnosis of CAD. Hence; the present study was undertaken with the aim of assessing the risk factors and clinical profile of CAD in female patients. Materials & methods:A hospital-based descriptive observational study was conducted with 100 patients to evaluate clinical profile and angiographic pattern in women with Coronary Artery Disease. Baseline demographics, clinical and risk factor profile was collected. Disease is defined as presence of stable angina, unstable angina or myocardial infarction. Baseline demographics, clinical and risk factor profile was collected. Appropriate statistical software, including but not restricted to MS-Excel. SPSS version 20 was used for statistical analysis. Graphical representation was done in MS-Excel 2010. Results:The mean age of the patients was 62.98 ± 12.60 years.The most common symptom was chest pain (82%) followed by shortness of breath (56%), sweating (38%), burning sensation in epigastrium (33%), palpitation (30%) and vomiting (9%). The most common vessel involved was Left Anterior Descending (LAD) (47.4%) followed by Right Coronary Artery (RCA) (28.9%) and Left Circumflex (LCX) (23.7%). There was no Left Main Coronary Artery (LMCA) lesion in our study. Conclusion:Chest pain is most common presenting symptom followed by shortness of breath, so these symptoms should never be ignored and should be investigated thoroughly to prove or to rule out CAD in women.