Background: Aerobic capacity depends on two factors one is the cardiac output and another one is the ventilatory capacity of the lungs, both of which are affected by exercise.Cardiopulmonary endurance requires a synchronized work between circulatory and respiratory systems. Aim and Objectives: To study the cardiopulmonary health of students.To study the correlation between VO2 Max with PFT among first-year MBBS students To study comparison of PFT, VO2 Max, & BMI in male & female first-yearMBBS students. Material and Methods: BMI was calculated using a weighing machine for weight and a stadiometer for height with the formula, BMI = weight/height 2 , the respiratory function was assessed by PFT. Aerobic capacity was calculated by Astrand 6-minute Cycle Test. Statistical analysis was done by unpaired t-test & Pearson correlation coefficient. Results: There has been a positive association between FVC, FEV1, FEV25-75, SVC, ERV, MVV, PEFR, LUNG Age, and VO2 Max. Statistically there was a significant difference observed in FVC, FEV1, FEF25-75, PEFR, SVC & statistically, there is no significant difference observed in ERV, lung age, BMI, VO2 Max between Male and female firstyearMBBS students Conclusion:Due to decreased physical activity, unhealthy lifestyle, overweight, and obesity, medical students are more prone to cardiopulmonary diseases. So, making them aware by doing simple tests and taking simple measures for a healthy lifestyle can prevent further complications.