Avascular necrosis (AVN) is a state where there is osteonecrosis due to lack of or interrupted blood supply to the bone. It is also termed as ischemic bone necrosis or aseptic necrosis. If unobstructed this process will eventually cause the bone to collapse. This is a backbreaking state in today’s times for Orthopaedists. In Ayurveda it can be corresponded to “Asthikshay”. This paper highlights a case study of Asthikshay (AVN) treated with Ayurvedic oral medications with Panchakarma Shodhan procedures. “Asthi is the site of Vata dosha”. Ashrayashrayee Bhava plays an essential role here. Vata-Kapha Dosha cause Srotodushti. Panchatikta Ksheera Basti along with other Ayurvedic medicines predominant in Tikta, Katu Rasa, Ushna Virya were used. Patient showed remarkable improvement in the condition in course of 60 days of treatment.