Introduction: Patients are frequently admitted to ICU (intensive care units) because of sepsis significant morbidity and death occur in intensive care unit patients with severe sepsis or shock. Sepsis has a mortality rate of 30-40%. Despite breakthroughs in sepsis treatment during the last two decades, mortality remains stable. Aims and objectives: To study the clinical profile of sepsis cases by monitoring the clinical parameters & latest scoring systems (SOFA &qSOFA) for critically ill patients. Materials and methods: This was a prospective observational study conducted at Sri Aurobindo Institute of Medical Sciences and PGI, Indore on 100 patients. Results: The distribution of patients according to comorbidities. Majority of the patients were having DM (62%) followed by HTN (45%) and IHD (9).Less number of patients were having Cyanotic heart disease (1), CLD (1), CVA (1), RA (1), and sickle cell anemia (1)